반응 #90253

반응 방정식

compound 11-4

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridin-9(10H)-one

Lawesson's reagent

→

title compound

수율 86.8%

2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H)-thione

수율 86.8%

용매

toluene

반응 조건

후처리

1. 1
   온도was refluxed for 4 hrs
2. 2
   기타Toluene was removed by evaporation
3. 3
   workup.ADDITIONTo the residue methanol (20 mL) was added
4. 4
   여과the product was collected by filtration
5. 5
   기타dried

실험 절차

A mixture of compound 11-4 (560 mg, 1 mmole), anhydrous toluene (10 mL) and Lawesson's reagent (820 mg, 2 mmole) was refluxed for 4 hrs. Toluene was removed by evaporation. To the residue methanol (20 mL) was added, stirred for few minutes at room temperature and the product was collected by filtration and dried to give 500 mg of the title compound. MS 576 (MH+).

출처