반응 #90211

ord-ac5a0278a69c441dbf19270139a5121e

반응 방정식

O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
isosorbide
CCCCCCCC(=O)O
caprylic acid
→
CCCCCCCC(=O)O[C@H]1CO[C@H]2[C@@H]1OC[C@H]2OC(=O)CCCCCCC
Isosorbide Dicaprylate

반응물

O[C@@H]1CO[C@H]2[C@@H]1OC[C@@H]2O
isosorbide
CCCCCCCC(=O)O
caprylic acid

시약

없음

용매

O
water

반응 조건

온도
180°CELSIUS
상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    workup.DISTILLATIONdistilled off (about 28 h)
  2. 2
    온도The temperature was then gradually increased to 210° C. (altogether over about 30 h)
  3. 3
    기타This gives a clear red-brown solution

실험 절차

In a stirred 1 liter apparatus under a stream of nitrogen, 219.0 g (1.5 mol) of isosorbide and 461.4 g (3.2 mol) of caprylic acid are heated with stirring and under a stream of nitrogen to 180° C. The reaction mixture was heated at 180° C. until no more water of reaction distilled off (about 28 h). The temperature was then gradually increased to 210° C. (altogether over about 30 h). The reaction has ended when a residual acid value of <2 mg KOH/g is reached. This gives a clear red-brown solution.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US09445595B2uspto-grants-2016_09