반응 #9019

반응 방정식

1,2-dibromoethane

tosyl cyanide

methyl-4(bromomethyl)benzoate

→

nitrile

수율 44.6%

4-bromomethyl-3-cyano-benzoic acid methyl ester

수율 44.6%

용매

THF

THF

THF

반응 조건

후처리

1. 1
   온도The mixture was cooled to room temperature
2. 2
   온도The mixture was cooled to 0° C.
3. 3
   workup.STIRRINGstirred for an additional 2 hours at 0° C
4. 4
   온도The reaction mixture was cooled to −78° C.
5. 5
   농축The mixture was concentrated under reduced pressure
6. 6
   workup.ADDITIONdiluted with CH2Cl2 (100 mL) and saturated aqueous NaHCO3 (15 mL)
7. 7
   여과filtered
8. 8
   기타The phases were separated
9. 9
   추출the aqueous layer was extracted with CH2Cl2 (3×50 mL)
10. 10
    건조The combined organic extracts were dried (MgSO4)
11. 11
    여과filtered
12. 12
    농축concentrated under reduced pressure
13. 13
    기타Purification by column chromatography on silica gel (Hexanes/EtOAc, 10:1)

실험 절차

A suspension of zinc dust (792 mg, 12.12 mmol) and 1,2-dibromoethane (44 μL, 0.51 mmol) in THF (3 mL) was stirred at 70° C. for 10 minutes. The mixture was cooled to room temperature and chlorotrimethylsilane (45 μL, 0.36 mmol) was added. The mixture was cooled to 0° C. and a solution of methyl-4(bromomethyl)benzoate (2.314 g, 10.10 mmol) in THF (11 mL) was added at 0° C. over 2 hours and then stirred for an additional 2 hours at 0° C. The reaction mixture was cooled to −78° C. and a solution of tosyl cyanide (1.556 g, 8.59 mmol) in THF (11 mL) was added and the resultant mixture stirred at room temperature for 16 hours. The mixture was concentrated under reduced pressure, diluted with CH2Cl2 (100 mL) and saturated aqueous NaHCO3 (15 mL) and filtered. The phases were separated and the aqueous layer was extracted with CH2Cl2 (3×50 mL). The combined organic extracts were dried (MgSO4), filtered and concentrated under reduced pressure. Purification by column chromatography on silica gel (Hexanes/EtOAc, 10:1) afforded the desired nitrile (973 mg) as a 16:1 mixture (desired product/side product).

출처