반응 #90144

반응 방정식

2-(1-benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid

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title compound

수율 63.0%

8-Methoxy-6,6-dimethyl-6H-benzo[b]naphth[2,3-d]thiophen-11-one

수율 63.0%

용매

water

반응 조건

후처리

1. 1
   온도under heating
2. 2
   추출extracted with ethyl acetate
3. 3
   세척washed with water
4. 4
   건조The organic layer was dried over magnesium sulfate
5. 5
   기타The residues obtained
6. 6
   농축after concentration under reduced pressure
7. 7
   기타were purified by silica gel column chromatography (ethyl acetate/hexane)

실험 절차

To 2-(1-benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid (Compound Z4, 68 mg, 0.22 mmol), polyphosphoric acid (3.5 g) was added, and the mixture was stirred for 1 hr at 100° C. under heating. The mixture was added with water, extracted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (41 mg, 63%).

출처