반응 #90092

반응 방정식

water

sodium hydroxide

2-(4-Isopropoxy-3-methoxy-phenyl)-2-methyl-propionic acid ethyl ester

→

2-(4-Isopropoxy-3-methoxy-phenyl)-2-methyl-propionic acid

용매

EtOH

THF

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate
2. 2
   추출extracted with ethyl acetate
3. 3
   세척washed with saturated brine
4. 4
   건조dried over sodium sulfate
5. 5
   기타The drying agent was removed by filtration
6. 6
   기타the residues obtained
7. 7
   농축after concentration under reduced pressure
8. 8
   기타were purified by silica gel column chromatography (ethyl acetate/hexane)
9. 9
   기타to obtain the target compound (white solid, 1.10 g, 84%)

실험 절차

2-(4-Isopropoxy-3-methoxy-phenyl)-2-methyl-propionic acid ethyl ester (Compound L3-1, 1.45 g, 5.17 mmol) was dissolved in THF (13 mL) and EtOH (13 mL), added with 1 N aqueous solution of sodium hydroxide (10.3 mL, 2.0 eq.), and stirred at 80° C. overnight. The reaction solution was added to water and extracted with ethyl acetate. The aqueous layer was acidified by using 1 N aqueous solution of hydrochloric acid, extracted with ethyl acetate, washed with saturated brine and dried over sodium sulfate. The drying agent was removed by filtration and the residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the target compound (white solid, 1.10 g, 84%).

출처