반응 #8994

반응 방정식

2-nitro-N-(4-bromo-3-trifluoromethylphenyl)benzamide

intermediate 1a

2-nitro-N-(4-bromo-3-trifluoromethylphenyl)benzamide

hydrogen

→

title compound

2-Amino-N-(4-bromo-3-trifluoromethylphenyl)benzamide

용매

methanol

반응 조건

후처리

1. 1
   여과The mixture is filtered
2. 2
   기타the solvent is evaporated under reduced pressure
3. 3
   기타to yield the crude product which
4. 4
   기타is purified by recrystallisation from diethylether-hexane

실험 절차

A solution of 2-nitro-N-(4-bromo-3-trifluoromethylphenyl)benzamide (intermediate 1a; 32 g, 82 mmol) in methanol (1000 mL) is hydrogenated at atmospheric pressure over Raney nickel (6 g) at 21° C. The calculated amount of hydrogen is taken up after 7 hours. The mixture is filtered and the solvent is evaporated under reduced pressure to yield the crude product which is purified by recrystallisation from diethylether-hexane to give the title compound as a colourless crystalline solid, m.p. 142–144° C.

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