반응 #8988

반응 방정식

(Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester

cyclopropylamine

→

(Z)-2-Acetylamino-3-cyclopropylamino-but-2-enoic acid ethyl ester

용매

water

acetic acid

반응 조건

후처리

1. 1
   기타evaporated under vacuum at 35° C
2. 2
   workup.ADDITIONWater (30 ml) was added to the residue
3. 3
   기타evaporated again at 35° C
4. 4
   기타to obtain the desired crude product as a dark brown oil [MS: m/e=227.4 (M+H+)], which
5. 5
   기타could be used without any further purification for the next step

실험 절차

(Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester (4.3 g, 20 mmol) and cyclopropylamine (1.14 g, 20 mmol) were stirred at room temperature in acetic acid (40 ml) for 2 hrs. The reaction mixture was diluted slowly with 30 ml of water and evaporated under vacuum at 35° C. Water (30 ml) was added to the residue and evaporated again at 35° C. The same procedure was repeated twice with toluene (30 ml each) to obtain the desired crude product as a dark brown oil [MS: m/e=227.4 (M+H+)], which could be used without any further purification for the next step.

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