반응 #8985

반응 방정식

Triphenylphosphine

2-Chloro-4-iodo-pyridine

trimethylsilylacetylene

→

desired product

2-Chloro-4-trimethylsilanylethynyl-pyridine

용매

triethyl amine

THF

반응 조건

후처리

1. 1
   기타This mixture was evacuated
2. 2
   기타to remove oxygen from the solution
3. 3
   workup.STIRRINGThe reaction mixture was stirred at room temperature overnight
4. 4
   기타The solvent was evaporated
5. 5
   추출extracted three times with ethyl acetate (500 mL each)
6. 6
   건조The combined organic extracts were dried with magnesium sulfate
7. 7
   여과filtered
8. 8
   기타evaporated
9. 9
   기타The crude product was purified by chromatography on silica gel (cyclohexane/ethyl acetate 80:20)

실험 절차

2-Chloro-4-iodo-pyridine (10.0 g, 41.8 mmol) was dissolved in 200 mL of dry THF and 17.5 mL of triethyl amine. This mixture was evacuated and backfilled with argon several times to remove oxygen from the solution. Triphenylphosphine (329 mg, 1.25 mmol) and bis(triphenylphosphine)palladium(II)chloride (1.47 g, 2.09 mmol) were added and the reaction mixture was stirred at room temperature for 1 h. Copper(I)iodide (239 mg, 1.25 mmol) and trimethylsilylacetylene (6.28 g, 6.39 mmol) were added. The reaction mixture was stirred at room temperature overnight. The solvent was evaporated. The residue was taken up in 500 mL of water and extracted three times with ethyl acetate (500 mL each). The combined organic extracts were dried with magnesium sulfate, filtered and evaporated. The crude product was purified by chromatography on silica gel (cyclohexane/ethyl acetate 80:20). The desired product was obtained as a light brown semi solid (10 g,>100%). This material was used without any further purification for the next step.

출처