반응 #89812

반응 방정식

4-chloro-2-(3-nitrophenyl)quinazoline

tert-butyl 5-amino-1H-indazole-1-carboxylate

→

tert-butyl 5-(2-(3-nitrophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate

용매

isopropanol

반응 조건

후처리

1. 1
   여과The suspension was filtered
2. 2
   세척the filtered solid was washed with isopropanol
3. 3
   기타The product was dried under high vacuum for several hours

실험 절차

A suspension of 4-chloro-2-(3-nitrophenyl)quinazoline (6.3 g, 21.9 mmole), tert-butyl 5-amino-1H-indazole-1-carboxylate (5.10 g, 21.9 mmole) in isopropanol (300 mL) was heated at 95° C. for 1.5 h. The suspension was filtered and the filtered solid was washed with isopropanol. The product was dried under high vacuum for several hours to give the desired product tert-butyl 5-(2-(3-nitrophenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate. (8.3 g, mmol, 79%).

출처