반응 #89785

반응 방정식

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester

→

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester

용매

piperidine

dimethylformamide

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under vacuum, water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   추출the product was extracted with ethyl acetate
4. 4
   기타The crude product was purified by conversion into its hydrochloride salt

실험 절차

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) was dissolved in 20% piperidine in dimethylformamide at 0° C. The solution was continued stirring for 1 h. The reaction mixture was concentrated under vacuum, water was added to the residue, and the product was extracted with ethyl acetate. The crude product was purified by conversion into its hydrochloride salt.

출처