반응 #89620

반응 방정식

Isoprene

dimethyl maleate

→

4-methyl-cyclohex-4-ene-1,2-dicarboxylic acid dimethyl ester

수율 66.7%

반응 조건

후처리

1. 1
   기타The autoclave was sealed
2. 2
   온도The temperature of the autoclave increased to 195° C. due to the
3. 3
   온도heat of the reaction
4. 4
   기타the completion of the reaction
5. 5
   온도The autoclave was then cooled to room temperature
6. 6
   workup.DISTILLATIONSimple distillation of the resulting mixture

실험 절차

Isoprene (350 g, 5.1 mol) and dimethyl maleate (741 g, 5.1 mol) were loaded into a stainless steel autoclave. The autoclave was sealed and heated to 150° C. The temperature of the autoclave increased to 195° C. due to the heat of the reaction. The temperature was held at 160° C. for 1 hour. Gas chromatography (GC) analysis indicated the completion of the reaction. The autoclave was then cooled to room temperature. Simple distillation of the resulting mixture provided 4-methyl-cyclohex-4-ene-1,2-dicarboxylic acid dimethyl ester (725 g, 3.4 mol, 66% yield) as a light yellow liquid.

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