반응 #89579

반응 방정식

HCl

Benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenyl-propanoate

HCl

→

benzyl (2S)-2-amino-3-phenyl-propanoate hydrochloride

용매

—

hexanes

diethyl ether

dioxane

반응 조건

후처리

1. 1
   여과filtered
2. 2
   기타to collect the title compound (7.98 g, 76%) as a fine white powder

실험 절차

Benzyl (2S)-2-(tert-butoxycarbonylamino)-3-phenyl-propanoate (12.8 g, 36 mmol) was stirred in HCl, 2 M in diethyl ether (90 mL) and HCl, 4 M in dioxane (18 mL) and the resulting mixture was stirred overnight at room temperature. The mixture was then diluted with hexanes (100 mL) and filtered to collect the title compound (7.98 g, 76%) as a fine white powder. 1H NMR (CD3OD, 400 MHz): δ (ppm) 7.40-7.15 (m, 10H), 5.23 (s, 2H), 4.36-4.31 (m, 1H), 3.26-3.12 (m, 2H).

출처