반응 #89565

반응 방정식

methyl 2,3-difluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

2-chloropyrimidine

K2CO3

→

title compound

Methyl 2,3-difluoro-6-(pyrimidin-2-yl)benzoate

용매

1,4-dioxane

water

반응 조건

후처리

1. 1
   온도The reaction mixture was cooled to rt
2. 2
   농축concentrated under reduced pressure
3. 3
   기타The resulting residue was directly purified by flash column chromatography on silica gel (0% to 50% EtOAc/hexanes)

실험 절차

A stirred suspension of methyl 2,3-difluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate, 2-chloropyrimidine, PdCl2(dppf) and K2CO3 in 1,4-dioxane and water (3:1, v/v) was heated at 90° C. under nitrogen for 18 h. The reaction mixture was cooled to rt and concentrated under reduced pressure. The resulting residue was directly purified by flash column chromatography on silica gel (0% to 50% EtOAc/hexanes) to give the title compound. ESI MS (M+H) 251.

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