반응 #8931

반응 방정식

aminodiphenylmethane

triethylamine

methyl 3-chlorosulfonyl-2(R)-methylpropionate

→

methyl 3-[N-(diphenylmethyl) aminosulfonyl]-2(R)-methylpropionate

수율 66.4%

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타A 100 mL round bottom flask equipped with magnetic stir bar
2. 2
   농축then concentrated in vacuo
3. 3
   세척The organic phase was washed with brine
4. 4
   기타dried
5. 5
   농축concentrated in vacuo

실험 절차

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1 g aminodiphenylmethane, 2 mL triethylamine in 20 mL CH2Cl2. The reaction was cooled to 0° C. and 1 g of methyl 3-chlorosulfonyl-2(R)-methylpropionate was slowly added. The reaction was stirred 1 hour then concentrated in vacuo. The residue was partioned between ethyl acetate and water. The organic phase was washed with brine, dried, and concentrated in vacuo. Trituration from Et2O/hexanes gave 1.15 g of methyl 3-[N-(diphenylmethyl) aminosulfonyl]-2(R)-methylpropionate as a white solid. HRMS (M+Li): calcd. 354.1351, obs 354.1569.

출처