반응 #893

반응 방정식

4,5-Dibromo-2-methyl-3(2H)-pyridazinone

sodium methoxide

→

desired product

4-Bromo-5-methoxy-2-methyl-3(2H)-pyridazinone

용매

methanol

methanol

반응 조건

후처리

1. 1
   기타The ice bath was removed
2. 2
   기타The methanol was removed by evaporation at reduced pressure
3. 3
   기타The residue was partitioned between dichloromethane and water
4. 4
   건조The organic layer was dried over magnesium sulfate
5. 5
   농축concentrated

실험 절차

4,5-Dibromo-2-methyl-3(2H)-pyridazinone (20 g, Maybridge Chemical Company) was cooled in an ice bath and treated successively with methanol (200 mL) and sodium methoxide (12 mL of a 30% solution in methanol). The ice bath was removed and the reaction was allowed to stir at 23° C. for 3 h. The methanol was removed by evaporation at reduced pressure. The residue was partitioned between dichloromethane and water. The organic layer was dried over magnesium sulfate and concentrated to provide the desired product 17 g as a whim solid melting at 146°-147° C. 1 H NMR (CDCl3): 7.7 (1H), 4.0 (3H), 3.8 (3H).

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