반응 #89280

반응 방정식

5-bromo-2-methylpyridine 1-oxide

trimethylsilyl cyanide

triethylamine

→

title compound

3-Bromo-6-methylpicolinonitrile

용매

acetonitrile

반응 조건

후처리

1. 1
   온도The mixture was cooled to rt
2. 2
   농축concentrated in vacuo
3. 3
   기타The crude was purified by silica gel chromatography

실험 절차

To the solution of 5-bromo-2-methylpyridine 1-oxide (8.935 g, 47.52 mmol) in acetonitrile (240 mL) was added trimethylsilyl cyanide (TMSCN) (25 mL, 190 mmol) and triethylamine (20 mL, 142.56 mmol). The reaction was heated at 100° C. for 16 h. The mixture was cooled to rt and concentrated in vacuo. The crude was purified by silica gel chromatography using 0-50% EtOAc in hexane to obtain the title compound.

출처