반응 #8924

반응 방정식

benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate

→

3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid

용매

MeOH

반응 조건

후처리

1. 1
   기타Hydrogenation at 50 psi for 48 hours afforded
2. 2
   여과after filtration
3. 3
   농축through Celite and concentration in vacuo

실험 절차

A 100 mL Fisher/Porter vessel was charged with benzyl 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionate in 15 mL MeOH with a catalytic amount of 10% Pd—C. Hydrogenation at 50 psi for 48 hours afforded, after filtration through Celite and concentration in vacuo to yield 3-[(4-methylpiperizin-1-yl)sulfonyl]-2(R)-methylpropionic acid as a hygroscopic foam suitable for use without further purification.

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