반응 #88911

반응 방정식

4-Bromo-2-hydroxybenzonitrile

ethylene carbonate

potassium carbonate

→

title compound

수율 56.1%

4-Bromo-2-(2-hydroxy-ethoxy)-benzonitrile

수율 56.1%

용매

DMF

반응 조건

후처리

1. 1
   기타The mixture was partitioned between EtOAc and water
2. 2
   추출The aqueous layer was then extracted with EtOAc (3×)
3. 3
   세척The combined organic layers were washed with brine
4. 4
   건조dried (MgSO4)
5. 5
   여과filtered
6. 6
   기타evaporated in vacuo
7. 7
   기타The residue was purified by FCC

실험 절차

4-Bromo-2-hydroxybenzonitrile (1.00 g, 5.05 mmol), ethylene carbonate (467 mg, 5.30 mmol) and potassium carbonate (348 mg, 2.52 mmol) were suspended in DMF (2.00 mL) and heated to 125° C. for 4.5 h. The mixture was partitioned between EtOAc and water. The aqueous layer was then extracted with EtOAc (3×). The combined organic layers were washed with brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by FCC, using 0-100% EtOAc in cyclohexane to give the title compound (686 mg, 56%). 1H NMR (300 MHz, d4-MeOD): 3.92 (2H, t, J=4.7 Hz), 4.21 (2H, t, J=4.7 Hz), 7.26 (1H, dd, J=8.2, 1.7 Hz), 7.44 (1H, d, J=1.6 Hz), 7.53 (1H, d, J=8.2 Hz).

출처