반응 #88885

반응 방정식

tert-butyl 4-(2,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate

HCl ethanol

→

title compound

4-(2,4-difluorobenzyl)-4-hydroxypiperidine hydrochloride

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   기타the obtained solid was recrystallized from ethyl acetate/diisopropyl ether

실험 절차

To a solution of tert-butyl 4-(2,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate (3.7 g) in ethanol (30 mL) was added 2.0 M HCl/ethanol solution (28 mL), and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethyl acetate/diisopropyl ether to give the title compound (2.9 g).

출처