반응 #88877
ord-0a27b93eed6d40d1858e2eaa50c774b8
반응 방정식
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출the mixture was extracted with ethyl acetate
- 2세척The extract was washed with saturated brine
- 3건조dried over anhydrous sodium sulfate
- 4여과filtered through basic silica gel
- 5농축The filtrate was concentrated under reduced pressure
실험 절차
A suspension of 2-chloronicotinic acid (0.20 g), 4-(4-cyanobenzyl)-4-hydroxypiperidine hydrochloride (0.32 g), HATU (0.72 g) and triethylamine (0.89 mL) in DMF (4.0 mL) was stirred overnight at room temperature. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over anhydrous sodium sulfate, and filtered through basic silica gel. The filtrate was concentrated under reduced pressure to give the title compound (0.45 g).