반응 #88870

반응 방정식

tert-butyl 4-(4-fluorobenzyl)-4-hydroxypiperidine-1-carboxylate

HCl ethanol

→

title compound

4-(4-fluorobenzyl)-4-hydroxypiperidine hydrochloride

용매

ethanol

반응 조건

후처리

1. 1
   기타The solvent was evaporated under reduced pressure
2. 2
   기타the obtained solid was recrystallized from ethanol/hexane

실험 절차

To a solution of tert-butyl 4-(4-fluorobenzyl)-4-hydroxypiperidine-1-carboxylate (2.0 g) in ethanol (10 mL) was added 2.0 M HCl/ethanol solution (20 mL), and the mixture was stirred at room temperature for 3 hr. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethanol/hexane to give the title compound (1.4 g).

출처