반응 #88657

반응 방정식

2-(4-chlorophenyl)furo[3,2-c]pyridin-4(5H)-one

6-bromo-2-cyclopropyl-1-methyl-1H-benzimidazole

N,N′-dimethylethylenediamine

potassium carbonate

→

title compound

수율 22.0%

2-(4-Chlorophenyl)-5-(2-cyclopropyl-1-methyl-1H-benzimidazol-6-yl)furo[3,2-c]pyridin-4(5H)-one

수율 22.0%

용매

DMSO

반응 조건

후처리

1. 1
   기타The reaction mixture was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
2. 2
   세척the obtained solid was washed with ethyl acetate

실험 절차

A mixture of 2-(4-chlorophenyl)furo[3,2-c]pyridin-4(5H)-one (100 mg), 6-bromo-2-cyclopropyl-1-methyl-1H-benzimidazole (123 mg), N,N′-dimethylethylenediamine (0.043 mL), copper(I) iodide (78.0 mg), potassium carbonate (169 mg) and DMSO (3.0 mL) was stirred at 190° C. for 1 hr under microwave irradiation. The reaction mixture was purified by silica gel column chromatography (NH, ethyl acetate/hexane), and the obtained solid was washed with ethyl acetate to give the title compound (37.3 mg) as a pale red solid.

출처