반응 #88226

반응 방정식

DCM

NaH

3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile

MeI

→

Compound C

3-fluoro-4-[methyl-(3-methylbenzimidazol-5-yl)amino]benzonitrile

용매

THF

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred at room temperature during 3 h
2. 2
   세척washed (H2O)
3. 3
   농축concentrated
4. 4
   기타The residue was purified by prep HPLC

실험 절차

NaH (7.14 mmol) was added to a solution of 3-fluoro-4-[(3-methylbenzimidazol-5-yl)amino]benzonitrile (2.38 mmol) in THF (10 mL) at 0° C. The mixture was stirred for 30 min. MeI (4.76 mmol) was added and the mixture was stirred at room temperature during 3 h. The mixture was diluted (DCM), washed (H2O) and concentrated. The residue was purified by prep HPLC to yield the desired product (Compound C).

출처