반응 #88219

반응 방정식

4-amino-3-fluorobenzonitrile

NCS

→

desired product

4-amino-3-chloro-5-fluoro-benzonitrile

용매

AcOH

반응 조건

후처리

1. 1
   농축The mixture was concentrated
2. 2
   workup.ADDITIONH2O was added to the residue
3. 3
   여과the solid product was filtered off
4. 4
   세척washed (sat. NaHCO3 and H2O)
5. 5
   workup.ADDITIONwas added
6. 6
   기타removed under reduced pressure

실험 절차

A mixture of 4-amino-3-fluorobenzonitrile (184 mmol) and NCS (276 mmol) in AcOH (300 mL) was stirred at 70° C. for approximately 16 h. The mixture was concentrated. H2O was added to the residue and the solid product was filtered off and washed (sat. NaHCO3 and H2O). To eliminate H2O, THF was added and removed under reduced pressure to yield the desired product.

출처