반응 #88218

반응 방정식

NH4Cl

2-bromo-4-methyl-5-nitropyridine

→

desired product

6-bromo-4-methyl-pyridin-3-ylamine

용매

H2O

반응 조건

후처리

1. 1
   workup.STIRRINGThe mixture was stirred at 90° C. for 1 h and 15 min
2. 2
   추출extracted with EtOAc
3. 3
   건조The organic layer was dried (Na2SO4)
4. 4
   농축concentrated

실험 절차

A mixture of NH4Cl (14.9 mmol) and iron powder (18.4 mmol) in H2O (5 mL) was stirred at 90° C. 2-bromo-4-methyl-5-nitropyridine (2.3 mmol) was added in portions. The mixture was stirred at 90° C. for 1 h and 15 min. The reaction was stopped and extracted with EtOAc. The organic layer was dried (Na2SO4) and concentrated to yield the desired product.

출처