반응 #88217

반응 방정식

2-fluoro-4-methylsulfonyl-aniline

KOAc

Br2

→

desired product

2-bromo-6-fluoro-4-methanesulfonyl-phenylamine

용매

AcOH

반응 조건

후처리

1. 1
   온도The mixture was cooled to 0° C.
2. 2
   workup.STIRRINGThe mixture was stirred for 30 min at 0° C
3. 3
   농축The mixture was concentrated
4. 4
   세척The organic mixture was washed (sat. NaHCO3, sat. Na2S2O3)
5. 5
   건조dried (Na2SO4)
6. 6
   농축concentrated

실험 절차

A mixture of 2-fluoro-4-methylsulfonyl-aniline (22.76 mmol) and KOAc (22.7 mmol) in AcOH was stirred at room temperature. The mixture was cooled to 0° C. and Br2 (22.7 mmol) was added dropwise. The mixture was stirred for 30 min at 0° C. The mixture was concentrated and the residue was taken up in EtOAc. The organic mixture was washed (sat. NaHCO3, sat. Na2S2O3), dried (Na2SO4) and concentrated to yield the desired product.

출처