반응 #88210

반응 방정식

MeNH2

5-bromo-1,3-difluoro-2-nitrobenzene

Cs2CO3

→

desired product

(5-Bromo-3-fluoro-2-nitro-phenyl)-methyl-amine

용매

THF

THF

반응 조건

후처리

1. 1
   workup.WAITat room temperature for 1 h
2. 2
   기타The solvent was removed under reduced pressure
3. 3
   기타The residue was partitioned between EtOAc and H2O
4. 4
   기타The two phases were separated
5. 5
   건조the organic layer was dried (Na2SO4)
6. 6
   농축concentrated

실험 절차

2 M MeNH2 in THF (82 mL) was added dropwise to a solution of 5-bromo-1,3-difluoro-2-nitrobenzene (164 mmol) and Cs2CO3 (197 mmol) in THF (1 L). The reaction mixture was stirred at 0° C. for 1 h and then at room temperature for 1 h. The solvent was removed under reduced pressure. The residue was partitioned between EtOAc and H2O. The two phases were separated and the organic layer was dried (Na2SO4) and concentrated to afford the desired product.

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