반응 #8819

반응 방정식

5-benzyl-1-m-tolyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

ammonium formate

→

1-m-tolyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine

수율 32.2%

용매

methanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux for 12 hr
3. 3
   기타to reach ambient temperature
4. 4
   기타The catalyst was removed by filtration through Celite®
5. 5
   기타The filtrate was evaporated in vacuo
6. 6
   기타Purification by silica gel chromatography

실험 절차

A mixture of 5-benzyl-1-m-tolyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 17a (500 mg, 1.6 mmol), ammonium formate (1.0 g), and 700 mg 5% Pd/C (50% with water) in 80% aqueous methanol was heated at reflux for 12 hr, and then allowed to reach ambient temperature. The catalyst was removed by filtration through Celite®. The filtrate was evaporated in vacuo. Purification by silica gel chromatography provided 1-m-tolyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine (110 mg) 18a as an oil.

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