반응 #8817

반응 방정식

2-chloro-6,7-dimethoxy-3H-quinazolin-4-one

1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine dihydrochloride

diisopropylethylamine

→

2-(1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-6,7-dimethoxy-3H-quinazolin-4-one

수율 29.9%

용매

2-methoxyethanol

water

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   기타to give an oil residue, which
3. 3
   기타The white precipitate that formed
4. 4
   여과was collected by filtration

실험 절차

A mixture of 2-chloro-6,7-dimethoxy-3H-quinazolin-4-one 1 (wherein R is methyl and Z is —C(O)—, 296 mg, 1.24 mmol), 1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridine dihydrochloride 15a (440 mg, 1.54 mmol)) and diisopropylethylamine (1.2 g, 9.26 mmol) in 2-methoxyethanol (10 mL) was stirred at 120° C. for 6 hours. The reaction mixture was concentrated in vacuo to give an oil residue, which was diluted with water. The white precipitate that formed was collected by filtration to give 155 mg of 2-(1-benzyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-6,7-dimethoxy-3H-quinazolin-4-one 501, [M+H]+=418.

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