반응 #88083

반응 방정식

4-amino-3-iodo-5-nitro-benzoic acid methyl ester

→

3,4-diamino-5-iodo-benzoic acid methyl ester

용매

ethyl acetate

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   기타partitioned between ethyl acetate
3. 3
   기타The organic layer was separated
4. 4
   건조dried over MgSO4
5. 5
   여과filtered
6. 6
   농축concentrated under reduced pressure

실험 절차

To a solution of 4-amino-3-iodo-5-nitro-benzoic acid methyl ester in ethyl acetate (50 mL) was added SnCl2 dihydrate. The mixture was heated to 70° C. for two hours, then cooled to room temperature and partitioned between ethyl acetate and satruated aqueous sodium bicarbonate. The organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to provide 1.68 g (quantitative) of 3,4-diamino-5-iodo-benzoic acid methyl ester.

출처