반응 #88078

반응 방정식

methyl iodide

3-iodo-4-methyl-5-nitro-benzoic acid

K2CO3

→

3-iodo-4-methyl-5-nitro-benzoic acid methyl ester

수율 98.3%

용매

acetone

반응 조건

후처리

1. 1
   온도cooled to room temperature
2. 2
   기타partitioned between ethyl acetate and brine
3. 3
   기타The organic layer was separated
4. 4
   건조dried over MgSO4
5. 5
   여과filtered
6. 6
   농축concentrated under reduced pressure

실험 절차

To a solution of 3-iodo-4-methyl-5-nitro-benzoic acid (16.06 g, 52.3 mmol) in acetone (300 mL) was added K2CO3 (14.46 g, 104.6 mmol) followed by methyl iodide ((3.91 mL, 62.76 mmol). The reaction mixture was stirred at 40° C. overnight, then cooled to room temperature and partitioned between ethyl acetate and brine. The organic layer was separated, dried over MgSO4, filtered and concentrated under reduced pressure to provide 16.5 g (98%) of 3-iodo-4-methyl-5-nitro-benzoic acid methyl ester.

출처