반응 #88071

반응 방정식

N-cyanopiperazine-1-carbimidothioate

N-((4-(((4-Bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochloride

N-((4-(((4-bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochloride

K2CO3

hydrazine monohydrate

→

N-((4-(((1-(3-amino-1H-1,2,4-triazol-5-yl)piperidin-4-yl)(4-bromophenethyl)amino)-methyl)phenyl)sulfonyl)acetamide

반응 조건

실험 절차

N-((4-(((4-Bromophenethyl)(piperidin-4-yl)amino)methyl)phenyl)sulfonyl)acetamide hydrochloride obtained in Step 2 was reacted with K2CO3 and S,S′-dimethyl-N-cyano-dithioiminocarbonate, followed by the cyclization of the intermediate (N-cyanopiperazine-1-carbimidothioate) with hydrazine monohydrate in a manner described in Procedure 3.

출처