반응 #88023

반응 방정식

methyl 3-(methylsulfonamido)thiophene-2-carboxylate

4-(2-chloroethyl)morpholine hydrochloride

DCM MeOH

potassium carbonate

→

methyl 3-(N-(2-morpholinoethyl)-methylsulfonamido)thiophene-2-carboxylate

용매

DMF

반응 조건

후처리

1. 1
   기타prepared in an analogous manner
2. 2
   기타The solvent was evaporated
3. 3
   workup.ADDITIONthe residue was diluted with EtOAc
4. 4
   세척washed with H2O and brine
5. 5
   건조the organic layer was dried over Na2SO4
6. 6
   여과filtered
7. 7
   기타evaporated
8. 8
   기타The crude was purified by flash chromatography on silica gel (DCM/EtOAc=8/2 to 7/3

실험 절차

A mixture of methyl 3-(methylsulfonamido)thiophene-2-carboxylate (prepared in an analogous manner as described in Example 8, Scheme 8, Step 1, 500 mg, 2.125 mmol), 4-(2-chloroethyl)morpholine hydrochloride (435 mg, 2.338 mmol) and potassium carbonate (646 mg, 4.68 mmol) in dry DMF (13 ml) was heated at 80° C. for 5 h and stirred at RT for 3 days. The solvent was evaporated, the residue was diluted with EtOAc and washed with H2O and brine; the organic layer was dried over Na2SO4, filtered and evaporated. The crude was purified by flash chromatography on silica gel (DCM/EtOAc=8/2 to 7/3 and then DCM/MeOH=95/5) to afford methyl 3-(N-(2-morpholinoethyl)-methylsulfonamido)thiophene-2-carboxylate (Int. 50) (655 mg, 1.880 mmol, MS/ESI+ 348.9 [MH]+).

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