반응 #88005

반응 방정식

methyl 1-(4-nitrophenylsulfonyl)-1H-pyrrole-2-carboxylate

lithium iodide

→

1-(4-nitrophenylsulfonyl)-1H-pyrrole-2-carboxylic acid

수율 82.5%

용매

pyridine

반응 조건

후처리

1. 1
   온도the resulting mixture was refluxed for 8 hours
2. 2
   농축The solution was concentrated under vacuum
3. 3
   workup.DISSOLUTIONthe crude was dissolved in DCM (150 ml)
4. 4
   세척washed with 1N HCl (50 ml×2)
5. 5
   건조the organic layer was dried over sodium sulfate
6. 6
   기타the solvent was removed

실험 절차

To a solution of methyl 1-(4-nitrophenylsulfonyl)-1H-pyrrole-2-carboxylate (Int. 4) (550 mg, 1.773 mmol) in pyridine (25 ml), lithium iodide (1661 mg, 12.41 mmol) was added and the resulting mixture was refluxed for 8 hours. The solution was concentrated under vacuum and the crude was dissolved in DCM (150 ml) and washed with 1N HCl (50 ml×2) and then with brine (50 ml); the organic layer was dried over sodium sulfate and the solvent was removed affording 1-(4-nitrophenylsulfonyl)-1H-pyrrole-2-carboxylic acid (Int. 5) (433 mg, 1.462 mmol).

출처