반응 #87980

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(S)-2-phenylpropanoic acid

sodium bicarbonate

ethanol

→

title compound

수율 84.0%

(S)-ethyl 2-phenylpropanoate

수율 84.0%

반응 조건

후처리

1. 1
   온도at reflux overnight in a vessel
2. 2
   기타equipped with a Dean-Stark condenser
3. 3
   여과the resulting mixture was filtered
4. 4
   농축concentrated under vacuum

실험 절차

To a solution consisting of (S)-2-phenylpropanoic acid (1.0 g, 6.7 mmol, from Chem-Impex) in ethanol (30 mL) was added concentrated sulfuric acid (4 drops). The reaction mixture was stirred at reflux overnight in a vessel equipped with a Dean-Stark condenser. To the mixture was added solid sodium bicarbonate and the resulting mixture was filtered and concentrated under vacuum to afford the title compound (1.0 g, 84%) as a colorless oil; TLC Rf 0.5 (solvent system: 15:85:1 v/v/v ethyl acetate-heptane-acetic acid). The product was carried directly onto the next step without further purification.

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