반응 #8796

반응 방정식

4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine

sodium hydride

5-piperidino-1-pentanol

→

4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine

용매

cyclohexane

반응 조건

후처리

1. 1
   온도under reflux for 4 hours

실험 절차

13.8 kg of 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine, 4.8 kg of 60% sodium hydride, 130 kg of cyclohexane and 10.6 kg of 5-piperidino-1-pentanol were stirred under reflux for 4 hours.

출처