반응 #87684

반응 방정식

3-fluoro-4-iodobenzonitrile

K2CO3

H2O2

→

desired title product

3-fluoro-4-iodobenzamide

용매

DMSO

반응 조건

후처리

1. 1
   기타After completion of the reaction
2. 2
   기타the reaction mass was quenched in ice cold water
3. 3
   여과The obtained solid product was filtered off

실험 절차

To a solution of 3-fluoro-4-iodobenzonitrile (2.7 g, 0.010 mmol) in DMSO (6.0 mL), K2CO3 (0.450 g, 0.003 mmol) and 30% H2O2 (2.4 mL) were added at 0-10° C. and the reaction mass was stirred at RT for 2 h. After completion of the reaction, the reaction mass was quenched in ice cold water. The obtained solid product was filtered off to afford 2.0 g of the desired title product. 1H NMR (400 MHz, DMSO d6): δ 7.48-7.51 (In, 2H), 7.66 (br s, 1H), 7.69-7.70 (m, 1H), 8.09 (brs, 1H).

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