반응 #87637

반응 방정식

2-chloro-4-fluorobenzoic acid

2,2,2-trifluoro-N-(hydroxymethyl)acetamide

→

desired product

5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid

용매

H2SO4

반응 조건

후처리

1. 1
   기타The title compound was prepared

실험 절차

The title compound was prepared according to the procedure described in step-1 of Intermediate-26 by using 2-chloro-4-fluorobenzoic acid (5.0 g, 0.002 mmol), 2,2,2-trifluoro-N-(hydroxymethyl)acetamide (4.0 g, 0.002 mmol) and conc. H2SO4 (50 mL) to afford 4.0 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 4.44 (d, J=12.0 Hz, 2H), 7.59 (m, 1H), 7.92 (m, 1H), 10.0 (br s, 1H), 13.5 (br s, 1H).

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