반응 #87602

반응 방정식

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

용매

methanol

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 18 h
2. 2
   농축The reaction mixture was concentrated
3. 3
   기타crude reaction mixture

실험 절차

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

출처