반응 #8758

반응 방정식

3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

potassium carbonate

3,4-dichlorobenzylamine

→

title compound

(3,4-dichloro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

용매

acetonitrile

반응 조건

후처리

1. 1
   세척is eluted
2. 2
   workup.ADDITIONa graded solvent mixture of 40% ethyl acetate in heptane

실험 절차

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 3,4-dichlorobenzylamine and acetonitrile essentially as described above in example 18 except that the column is eluted using a graded solvent mixture of 40% ethyl acetate in heptane, to 100% ethyl acetate. Purity by LC/MS (APCI)=100%, [M+H]+=419.

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