반응 #8752

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3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

4-(2-aminoethyl) benzenesulfonamide

potassium carbonate

→

title compound

수율 35.0%

4-{2-[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propylamino]-ethyl}-benzenesulfonamide

수율 35.0%

반응 조건

후처리

1. 1
   세척is eluted
2. 2
   workup.ADDITIONa graded solvent mixture of dichloromethane:methanol (90:10)
3. 3
   농축Combine the appropriate fractions and concentrate

실험 절차

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 4-(2-aminoethyl) benzenesulfonamide and potassium carbonate essentially as described above in example 4 except that the column is eluted using a graded solvent mixture of dichloromethane:methanol (90:10). Combine the appropriate fractions and concentrate to give the title compound (0.16 g, 35% Yield) as a solid. Purity by LC/MS (APCI)=96% area, [M+H]+=458 m/e.

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