반응 #8750

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3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

1-(2-fluorophenyl) piperazine

potassium carbonate

→

title compound

수율 100.0%

3-(3-{3-[4-(2-fluoro-phenyl)-piperazin-1-yl]-propoxy}-phenyl)-thieno[2,3-d]isoxazole

수율 100.0%

반응 조건

후처리

1. 1
   세척is eluted with a mixture of dichloromethane:methanol (98:2)
2. 2
   농축Combine the appropriate fractions and concentrate

실험 절차

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 1-(2-fluorophenyl) piperazine and potassium carbonate essentially as described above in example 4 except that the column is eluted with a mixture of dichloromethane:methanol (98:2). Combine the appropriate fractions and concentrate to give the title compound (0.45 g, 100% Yield) as a solid. Purity by LC/MS (APCI)=100% area, [M+H]+=438 m/e.

출처