반응 #8746

반응 방정식

3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-(aminomethyl)pyridine

potassium carbonate

→

title compound

수율 77.0%

pyridin-3-ylmethyl-[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-amine

수율 77.0%

반응 조건

후처리

1. 1
   농축Combine the appropriate fractions and concentrate

실험 절차

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-(aminomethyl)pyridine and potassium carbonate essentially as described above in example 4. Combine the appropriate fractions and concentrate to give the title compound (0.28 g, 77% Yield) as and oil. Purity by LC/MS (APCI)=98% area, [M+H]+=366 m/e.

출처