반응 #8745

반응 방정식

3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-thiophenemethylamine

potassium carbonate

→

title compound

수율 86.0%

[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-thiophen-3-yl-methylamine

수율 86.0%

반응 조건

후처리

1. 1
   농축Combine the appropriate fractions and concentrate

실험 절차

The title compound is prepared from a mixture of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-thiophenemethylamine and potassium carbonate essentially as described above in example 4. Combine the appropriate fractions and concentrate to give the title compound (0.32 g, 86% Yield) as an oil. Purity by LC/MS (APCI)=98%, [M+H]+=371 m/e.

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