반응 #8740

반응 방정식

3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole

3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole

2-fluorobenzylamine

potassium carbonate

→

title compound

수율 94.1%

(2-fluoro-benzyl)-[3-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-propyl]-amine

수율 94.1%

용매

acetonitrile water

반응 조건

후처리

1. 1
   온도Cool the reaction mixture
2. 2
   농축concentrate
3. 3
   기타to give a residue
4. 4
   기타Purify the residue by column (silica) chromatography (ethyl acetate)
5. 5
   농축Combine the appropriate fractions and concentrate

실험 절차

Combine a mixture (1 mmol total) of 3-[3-(3-bromo-propoxy)-phenyl]-thieno[2,3-d]isoxazole, 3-[3-(3-chloro-propoxy)-phenyl]-thieno[2,3-d]isoxazole with 2-fluorobenzylamine (0.63 g, 5.0 mmol), potassium carbonate (0.41 g, 3.0 mmol) and a mixture of acetonitrile:water (80:20) and heat (80° C.) for 30 hours. Cool the reaction mixture and concentrate to give a residue. Purify the residue by column (silica) chromatography (ethyl acetate). Combine the appropriate fractions and concentrate to give the title compound (0.36 g, 94% Yield) as an oil. Purity by LC/MS (APCI)=100% area, [M+H]+=383 g/mol.

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