반응 #87382

반응 방정식

cyclopropylmethanamine

2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

→

title compound

2-Chloro-N-(cyclopropylmethyl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

용매

MeOH

acetonitrile

반응 조건

후처리

1. 1
   농축The solution was concentrated
2. 2
   기타purified by preparative HPLC

실험 절차

A solution of cyclopropylmethanamine (91 mg, 1.28 mmol) a in MeOH (2 mL) was added to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (111 mg, 0.43 mmol) in acetonitrile (2 mL). The mixture was stirred at ambient temperature overnight. The solution was concentrated and purified by preparative HPLC to give the title compound as a solid, 72 mg (58%).

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