반응 #87293

반응 방정식

2-(4-chlorobenzylidene)indan-1-one

N-bromosuccinimide

benzoyl peroxide

→

14a

3-Bromo-2-(4-chlorobenzylidene)indan-1-one

용매

CCl4

반응 조건

후처리

1. 1
   온도under reflux for one hour
2. 2
   여과filtered once
3. 3
   기타The precipitate was separated

실험 절차

2-(4-chlorobenzylidene)indan-1-one (2.44 g, 9.58 mmol) was dissolved in 35 mL of CCl4. N-bromosuccinimide (1.685 g, 9.58 mmol) and benzoyl peroxide (122 mg, 0.52 mmol) were added in one portion. The solution was then stirred under reflux for one hour and then filtered once cooled to room temperature. The precipitate was separated using flash column chromatography (15:1 Hexanes/EtOAc) provided 14a as white crystals.

출처