반응 #87154

반응 방정식

(R)-benzyl 2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoate

→

(R)-2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoic acid

수율 131.6%

용매

MeOH

반응 조건

후처리

1. 1
   여과Pd/C was filtered off
2. 2
   세척washed with MeOH (5 mL)
3. 3
   농축concentrated to dryness

실험 절차

Pd/C (10%, 1 g) was added to a solution of compound (R)-benzyl 2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoate (500 mg, 1.7 mmol) in MeOH (20 mL). The suspension was stirred under hydrogen atmosphere at ambient temperature for 2 h. Pd/C was filtered off and washed with MeOH (5 mL). The filtrate and washings were combined and concentrated to dryness to afford (R)-2-((1R,3S)-3-hydroxycyclopentanecarboxamido)propanoic acid (450 mg, quantitative). (R)-2-((1S,3R)-3-hydroxycyclopentanecarboxamido)propanoic acid was obtained in a similar manner.

출처