반응 #87133

반응 방정식

S—Phos

2-(benzyloxy)-4-bromo-1-methylbenzene

(R)-methyl 2-(tert-butoxycarbonylamino)-3-iodopropanoate

iodine

→

(S)-methyl 3-(3-(benzyloxy)-4-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoate

수율 37.1%

용매

DMF

water

EtOAc

반응 조건

후처리

1. 1
   기타dried flask under N2
2. 2
   workup.STIRRINGThe reaction mixture was stirred at 60° C. for 6 h
3. 3
   온도then cooled to ambient temperature
4. 4
   기타the organic phase was separated
5. 5
   세척washed with water (300 mL×3) and brine (300 mL×1)
6. 6
   건조dried over anhydrous sodium sulfate
7. 7
   농축concentrated
8. 8
   기타The residue was purified by flash column chromatography on silica gel (hexane/EtOAc=10:1)

실험 절차

Dry DMF (100 mL) was added to zinc dust (7.00 g, 108 mmol) in a flame dried flask under N2. (R)-methyl 2-(tert-butoxycarbonylamino)-3-iodopropanoate (9.7 g, 29 mmol) and a catalytic amount of iodine (0.7 g, 2 mmol) were added. The mixture was stirred at ambient temperature for 0.5 h, then Pd2(dba)3 (1.9 g, 2.0 mmol), S—Phos (1.6 g, 4.0 mmol) and 2-(benzyloxy)-4-bromo-1-methylbenzene (7.40 g, 27.0 mmol) were added. The reaction mixture was stirred at 60° C. for 6 h then cooled to ambient temperature. EtOAc (500 mL) and water (500 mL) were added and the organic phase was separated, washed with water (300 mL×3) and brine (300 mL×1), dried over anhydrous sodium sulfate, and concentrated. The residue was purified by flash column chromatography on silica gel (hexane/EtOAc=10:1) to afford (S)-methyl 3-(3-(benzyloxy)-4-methylphenyl)-2-((tert-butoxycarbonyl)amino)propanoate (4.0 g, 37% yield).

출처