반응 #871

반응 방정식

HCl dioxane

N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine

→

(R)-α-ethoxymethylbenzylamine hydrochloride

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure, 30 ml of ether
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   농축this was further concentrated

실험 절차

12.5 ml of 4N-HCl/dioxane solution were added to 0.66 g (2.5 mmols) of N-t-butoxycarbonyl-(R)-α-ethoxymethylbenzylamine, and the mixture was stirred at room temperature for one hour. The reaction mixture was concentrated under reduced pressure, 30 ml of ether was added to the residue, and this was further concentrated to obtain (R)-α-ethoxymethylbenzylamine hydrochloride at a quantitative yield.

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